Autoprocessing of human immunodeficiency virus type 1 protease miniprecursor fusions in mammalian cells
Abstract Background HIV protease (PR) is a virus-encoded aspartic protease that is essential for viral replication and infectivity.The fully active and mature dimeric protease is released Headphones from the Gag-Pol polyprotein as a result of precursor autoprocessing.Results We here describe a simple model system to directly examine HIV protease au